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cdk3 protein  (Human Protein Atlas)

 
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    Structured Review

    Human Protein Atlas cdk3 protein
    Overview of CDKs-cyclin complexes and their main regulators
    Cdk3 Protein, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cdk3 protein/product/Human Protein Atlas
    Average 90 stars, based on 1 article reviews
    cdk3 protein - by Bioz Stars, 2026-03
    90/100 stars

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    1) Product Images from "Cyclin-dependent protein kinases and cell cycle regulation in biology and disease"

    Article Title: Cyclin-dependent protein kinases and cell cycle regulation in biology and disease

    Journal: Signal Transduction and Targeted Therapy

    doi: 10.1038/s41392-024-02080-z

    Overview of CDKs-cyclin complexes and their main regulators
    Figure Legend Snippet: Overview of CDKs-cyclin complexes and their main regulators

    Techniques Used: Phospho-proteomics, Activation Assay, Activity Assay, HAT Assay, Binding Assay

    Cell Cycle Progression via EGFR and Receptor Tyrosine Kinase Signaling . EGFR stimulation promotes the activation of the CycC-CDK3 complex, enabling the cell to exit quiescence (G0) and enter the G1 phase by priming RB phosphorylation. Activation of various Receptor Tyrosine Kinases (RTKs) can similarly promote G1 progression through signal cascades involving RAS-GTP and its downstream RAF/MEK/ERK and PI3K/AKT/mTOR pathways. These signaling cascades lead to the formation and activation of CycD-CDK4/6 complexes and their translocation to the nucleus. In the nucleus, CycD-CDK4/6 complexes further phosphorylate RB. The inhibition of RB allows the accumulation of E2F on DNA, promoting the transcription of genes essential for cell cycle progression and DNA replication. Subsequently, the activation of the CycE-CDK2 complex drives the transition from G1 to S phase by hyper-phosphorylating RB, enabling cell cycle progression independently of growth factor stimuli (bypassing the restriction point). The accumulation of CycA and the displacement of CycE from the CycE-CDK2 complex facilitate the formation of the CycA-CDK2 complex, which drives S phase entry, progression, and DNA synthesis. Following faithful DNA replication, the CycA-CDK1 complex triggers entry into mitosis. This is followed by the formation and activation of the CycB-CDK1 complex, which is necessary for the completion of proper cell division. The roles of activating proteins (such as CAK and CDC25A/B/C) and inhibitory proteins (such as CDK inhibitors, WEE1, and MYT1) on specific cyclin-CDK complexes are indicated by black arrows. Abbreviations used: RTKs Receptor Tyrosine Kinase, CAK complex CDK Activating Kinase complex, CycA cyclin A, CycB cyclin B, CycC cyclin C, CycD cyclin D, CycE cyclin E, CDC25 Cell Division Cycle 25. (Adapted from “Cell Cycle Checkpoints”, “RAS Pathway”, by BioRender.com (2024)
    Figure Legend Snippet: Cell Cycle Progression via EGFR and Receptor Tyrosine Kinase Signaling . EGFR stimulation promotes the activation of the CycC-CDK3 complex, enabling the cell to exit quiescence (G0) and enter the G1 phase by priming RB phosphorylation. Activation of various Receptor Tyrosine Kinases (RTKs) can similarly promote G1 progression through signal cascades involving RAS-GTP and its downstream RAF/MEK/ERK and PI3K/AKT/mTOR pathways. These signaling cascades lead to the formation and activation of CycD-CDK4/6 complexes and their translocation to the nucleus. In the nucleus, CycD-CDK4/6 complexes further phosphorylate RB. The inhibition of RB allows the accumulation of E2F on DNA, promoting the transcription of genes essential for cell cycle progression and DNA replication. Subsequently, the activation of the CycE-CDK2 complex drives the transition from G1 to S phase by hyper-phosphorylating RB, enabling cell cycle progression independently of growth factor stimuli (bypassing the restriction point). The accumulation of CycA and the displacement of CycE from the CycE-CDK2 complex facilitate the formation of the CycA-CDK2 complex, which drives S phase entry, progression, and DNA synthesis. Following faithful DNA replication, the CycA-CDK1 complex triggers entry into mitosis. This is followed by the formation and activation of the CycB-CDK1 complex, which is necessary for the completion of proper cell division. The roles of activating proteins (such as CAK and CDC25A/B/C) and inhibitory proteins (such as CDK inhibitors, WEE1, and MYT1) on specific cyclin-CDK complexes are indicated by black arrows. Abbreviations used: RTKs Receptor Tyrosine Kinase, CAK complex CDK Activating Kinase complex, CycA cyclin A, CycB cyclin B, CycC cyclin C, CycD cyclin D, CycE cyclin E, CDC25 Cell Division Cycle 25. (Adapted from “Cell Cycle Checkpoints”, “RAS Pathway”, by BioRender.com (2024)

    Techniques Used: Activation Assay, Phospho-proteomics, Translocation Assay, Inhibition, DNA Synthesis

    The Role of CDKs in cancer
    Figure Legend Snippet: The Role of CDKs in cancer

    Techniques Used:



    Similar Products

    cdk3 protein  (Human Protein Atlas)
    90
    Human Protein Atlas cdk3 protein
    Overview of CDKs-cyclin complexes and their main regulators
    Cdk3 Protein, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cdk3 protein/product/Human Protein Atlas
    Average 90 stars, based on 1 article reviews
    cdk3 protein - by Bioz Stars, 2026-03
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Overview of CDKs-cyclin complexes and their main regulators

    Journal: Signal Transduction and Targeted Therapy

    Article Title: Cyclin-dependent protein kinases and cell cycle regulation in biology and disease

    doi: 10.1038/s41392-024-02080-z

    Figure Lengend Snippet: Overview of CDKs-cyclin complexes and their main regulators

    Article Snippet: CDK3 (305 amino acids, located at 17q25.1) is a protein predominantly localized in the cytosol, with high expression in the respiratory tract according to the Human Protein Atlas.

    Techniques: Phospho-proteomics, Activation Assay, Activity Assay, HAT Assay, Binding Assay

    Cell Cycle Progression via EGFR and Receptor Tyrosine Kinase Signaling . EGFR stimulation promotes the activation of the CycC-CDK3 complex, enabling the cell to exit quiescence (G0) and enter the G1 phase by priming RB phosphorylation. Activation of various Receptor Tyrosine Kinases (RTKs) can similarly promote G1 progression through signal cascades involving RAS-GTP and its downstream RAF/MEK/ERK and PI3K/AKT/mTOR pathways. These signaling cascades lead to the formation and activation of CycD-CDK4/6 complexes and their translocation to the nucleus. In the nucleus, CycD-CDK4/6 complexes further phosphorylate RB. The inhibition of RB allows the accumulation of E2F on DNA, promoting the transcription of genes essential for cell cycle progression and DNA replication. Subsequently, the activation of the CycE-CDK2 complex drives the transition from G1 to S phase by hyper-phosphorylating RB, enabling cell cycle progression independently of growth factor stimuli (bypassing the restriction point). The accumulation of CycA and the displacement of CycE from the CycE-CDK2 complex facilitate the formation of the CycA-CDK2 complex, which drives S phase entry, progression, and DNA synthesis. Following faithful DNA replication, the CycA-CDK1 complex triggers entry into mitosis. This is followed by the formation and activation of the CycB-CDK1 complex, which is necessary for the completion of proper cell division. The roles of activating proteins (such as CAK and CDC25A/B/C) and inhibitory proteins (such as CDK inhibitors, WEE1, and MYT1) on specific cyclin-CDK complexes are indicated by black arrows. Abbreviations used: RTKs Receptor Tyrosine Kinase, CAK complex CDK Activating Kinase complex, CycA cyclin A, CycB cyclin B, CycC cyclin C, CycD cyclin D, CycE cyclin E, CDC25 Cell Division Cycle 25. (Adapted from “Cell Cycle Checkpoints”, “RAS Pathway”, by BioRender.com (2024)

    Journal: Signal Transduction and Targeted Therapy

    Article Title: Cyclin-dependent protein kinases and cell cycle regulation in biology and disease

    doi: 10.1038/s41392-024-02080-z

    Figure Lengend Snippet: Cell Cycle Progression via EGFR and Receptor Tyrosine Kinase Signaling . EGFR stimulation promotes the activation of the CycC-CDK3 complex, enabling the cell to exit quiescence (G0) and enter the G1 phase by priming RB phosphorylation. Activation of various Receptor Tyrosine Kinases (RTKs) can similarly promote G1 progression through signal cascades involving RAS-GTP and its downstream RAF/MEK/ERK and PI3K/AKT/mTOR pathways. These signaling cascades lead to the formation and activation of CycD-CDK4/6 complexes and their translocation to the nucleus. In the nucleus, CycD-CDK4/6 complexes further phosphorylate RB. The inhibition of RB allows the accumulation of E2F on DNA, promoting the transcription of genes essential for cell cycle progression and DNA replication. Subsequently, the activation of the CycE-CDK2 complex drives the transition from G1 to S phase by hyper-phosphorylating RB, enabling cell cycle progression independently of growth factor stimuli (bypassing the restriction point). The accumulation of CycA and the displacement of CycE from the CycE-CDK2 complex facilitate the formation of the CycA-CDK2 complex, which drives S phase entry, progression, and DNA synthesis. Following faithful DNA replication, the CycA-CDK1 complex triggers entry into mitosis. This is followed by the formation and activation of the CycB-CDK1 complex, which is necessary for the completion of proper cell division. The roles of activating proteins (such as CAK and CDC25A/B/C) and inhibitory proteins (such as CDK inhibitors, WEE1, and MYT1) on specific cyclin-CDK complexes are indicated by black arrows. Abbreviations used: RTKs Receptor Tyrosine Kinase, CAK complex CDK Activating Kinase complex, CycA cyclin A, CycB cyclin B, CycC cyclin C, CycD cyclin D, CycE cyclin E, CDC25 Cell Division Cycle 25. (Adapted from “Cell Cycle Checkpoints”, “RAS Pathway”, by BioRender.com (2024)

    Article Snippet: CDK3 (305 amino acids, located at 17q25.1) is a protein predominantly localized in the cytosol, with high expression in the respiratory tract according to the Human Protein Atlas.

    Techniques: Activation Assay, Phospho-proteomics, Translocation Assay, Inhibition, DNA Synthesis

    The Role of CDKs in cancer

    Journal: Signal Transduction and Targeted Therapy

    Article Title: Cyclin-dependent protein kinases and cell cycle regulation in biology and disease

    doi: 10.1038/s41392-024-02080-z

    Figure Lengend Snippet: The Role of CDKs in cancer

    Article Snippet: CDK3 (305 amino acids, located at 17q25.1) is a protein predominantly localized in the cytosol, with high expression in the respiratory tract according to the Human Protein Atlas.

    Techniques: